Endocrine Abstracts

Ossification defects have been described in patients with peroxisomal disorders, autosomal-recessive diseases due to the impairment of peroxisome biogenesis. However, the functions of peroxisomes in skeletal tissues are unknown. In the present study, we used a knockout (KO) mouse model, defective in the PEX11β gene, to investigate the molecular pathogenesis of the ossification defect. Alizarin Red/Alzian Blue stainings, flat-panel volume-CT (fpvCT), and immunofluorescence...